Protein kinase C (PKC) is a prominent target for design of anti-cancer chemotherapeutic drugs.  The occurrence of PKC as several isoforms that are structurally-related and sometimes functionally distinct complicates strategies for targeting a single isoform.  This laboratory is focused on identifying intracellular substrates of specific PKC isoforms for the purpose of defining the signaling enzymatic components of isoform-stimulated pathways, and consequently to use these components as targets of chemotherapeutic agents.  Targeting of a PKC isoform and one or more of its downstream targets will result in blockade of the pathway for that isoform